Biomedical Electronics

Oliver Hayden

Oliver Hayden studied biochemistry at the University of Vienna, Austria, where he finished his doctorate in 1999. After his postdoc at Harvard University, USA, and his completion of the venia docendi for Analytical Chemistry at the University of Vienna, he left academia to pursue his interests in industrial research. He joined IBM Research Laboratory Zürich, Switzerland, to work on post-CMOS technologies and moved to Siemens Erlangen, Germany, where he worked on various medical technologies, such as organic electronics for imaging and in-vitro diagnostics of blood cells. In 2017 he returned to academia and was appointed as head of the Heinz-Nixdorf-Chair of Biomedical Electronics. In March 2019, he additionally took over the management of the TranslaTUM as Director.

 

Research Focus

In vitro diagnostics covers medtech products to diagnose patient samples in a central laboratory and at the point-of-care. The involved sample logistics and pre-analytics are limiting the application of living biomarkers for both fields of applications in the routine. Cells are the smallest integral unit of life showing a plethora of functions with high relevance for clinical and preclinical diagnostics. The Heinz-Nixdorf-Chair of Biomedical Electronics is therefore interested to develop new methods for cell function diagnostics with the goal to provide biomarker over various time constants for routine applications. To achieve our goals we develop an understanding of workflows and biomarkers to cooperate for our interdisciplinary research projects with a network of academic, clinical, and industrial partners.

Currently, we are applying electronic, optical, and magnetic sensors for cell function diagnostics. Microfluidics is used applied as platform technology for precision guiding of cells and cell aggregates. Projects CellTIVITY and CellFACE are core technologies of the Chair to develop magnetic and imaging-based flow cytometry workflows, respectively, with minimum or no sample preparation effort. CellTEST and CellLEGO are high-throughput compatible methods for long-term in vitro cell test studies of patient samples and precise cell-cell interaction studies in 3D. In general, our projects are solution-oriented and less technology-driven research approaches for a future translation of technology and teams.
TranslaTUM enables the Chair to develop a unique relationship for electrical engineering to preclinical and clinical users. We believe in an open culture to accelerate research and to foster the strength of TUM’s goal of an entrepreneurial Technical University. At the same time, we consider ourselves a mediator at the campus of Klinikum Rechts der Isar for clinician, industry or academic groups, and for young talents aiming for startups.

Students interested in joining our team at TranslaTUM will have the opportunity to work in interdisciplinary teams and be exposed to different research cultures, which would allow them to develop a skillset for a career in medtech industry. To learn if biomedical engineering is a match we offer students research projects with industry partners and curricula with industry lecturers.

Key Awards

  • European Inventor Award (2017)
  • AMA Innovation Award (2016)
  • Siemens NTF Award for Medical Imaging Patents (2013)
  • Young Investigator Award of the Society of Austrian Chemists (2002)

Selected Publications

  • Hefele M., Wirths W., Brischwein M., Grothe H., Kreupl F., Wolf B.: Measuring fluorescence-lifetime and bio-impedance sensors for cell based assays using a network analyzer integrated circuit. Biosensors & Bioelectronics. 2018 Sep 13; doi: 10.1016/j.bios.2018.09.053. [Epub ahead of print]
  • Maas M.B, Brischwein M., Los P., Perold W.J., Dicks L.: Evaluating non-linear impedance excitation as detection method for biosensors. IEEE Transactions on Nanotechnology. 2018, PP(99):1-1, DOI: 10.1109/TNANO.2018.2864572
  • Ugele M., Weniger M., Stanzel M., Bassler M., Krause S.W., Friedrich O., Hayden O.,5, Richter L.: Label-Free High-Throughput Leukemia Detection by Holographic Microscopy. Adv Sci (Weinh). eCollection, 2018 Oct 11;5(12):1800761. doi: 10.1002/advs.201800761.
  • Brischwein M., Wiest J.: Microphysiometry. In: Bioanalytical Reviews. Springer, Berlin, Heidelberg, 2018
  • Ugele M., Weniger M., Leidenberger M., Huang Y., Bassler M., Friedrich O., Kappes B., Hayden O., Richter L.: Label-free, high-throughput detection of P. falciparum infection in sphered erythrocytes with digital holographic microscopy. Lab Chip. 2018 Jun 12;18(12):1704-1712. doi: 10.1039/c8lc00350e.
  • Reisbeck M., Richter L., Helou M.J., Arlinghaus S., Anton B., van Dommelen I., Nitzsche M., Baßler M., Kappes B., Friedrich O., Hayden O.: Hybrid integration of scalable mechanical and magnetophoretic focusing for magnetic flow cytometry. Biosens Bioelectron. 2018 Jun 30;109:98-108. doi: 10.1016/j.bios.2018.02.046. Epub 2018 Mar 15.
  • Barnkob R., Nama N., Ren L., Huang T. J., Costanzo F., and Kähler C. J.: Acoustically Driven Fluid and Particle Motion in Confined and Leaky Systems, Phys Rev Applied, 2018, 9, 014027
  • Reisbeck M., Helou M.J., Richter L., Kappes B., Friedrich O., Hayden O.: Magnetic fingerprints of rolling cells for quantitative flow cytometry in whole blood. Scientific reports. 2016;6:32838.
  • Hayden O.: One Binder to Bind Them All. Sensors. 2016;16(10):1665.
  • Wirth R., Ugele M., Wanner G.: Motility and Ultrastructure of Spirochaeta thermophila. Front Microbiol. eCollection, 2016 Oct 14;7:1609.
  • Wiest J, Namias A, Pfister C, Wolf P, Demmel F, Brischwein M.: Data Processing in Cellular Microphysiometry. IEEE Transactions on Biomedical Engineering. 2016, 63:2368-2375