Experimental Radiation Oncology and Radiobiology

Gabriele Multhoff 

After studying biology at LMU Munich, Gabriele Multhoff completed her Ph.D. in 1990, having conducted research in the field of immunology. While she was working toward her postdoctoral teaching qualification (habilitation), which she acquired in 1998, she was supported by a Möllemann Habilitation stipend. In 2002 she became a professor of “Experimental Hematology” at the University Hospital Regensburg before being appointed professor for “Experimental Radiooncology and Radiation Biology” at Klinikum rechts der Isar at TUM in 2007. She holds a Zweitmitgliedschaft at the „Wissenschaftszentrum Weihenstephan“ in Freising. In 2004 she became “consultant immunologist”. Between 2007 and 2009 she was president of the “Cell Stress Society International” (CSSI). Prof. Multhoff is founder and CSO of the biotech company multimmune GmbH and holds more than 15 patents. She is a commissioner of the German Academic Exchange Service (DAAD) and the EU, as well as a member of numerous professional and scientific associations.

 

Research Focus

One of the focus areas of Prof. Gabriele Multhoff’s research work is the development of innovative cell-, molecule- and antibody-based targeted immunotherapies based on heat shock proteins (SFB 824: in vivo imaging). The aim is to combine these new therapeutic approaches with conventional radiation therapy and chemotherapy. Her current research work has led to a randomized, multicenter clinical phase II study entitled “Targeted NK cell-based adjuvant immunotherapy for the treatment of patients with non-small cell lung carcinoma (NSCLC) after radiochemotherapy” funded by the German Federal Ministry of Education and Research (BMBF). To stratify patients who most likely will benefit from Hsp70-targeting therapies, her group established a novel screening test (lipHsp70 ELISA, patent) to quantify liposomal, tumor-derived Hsp70 and a method to isolate circulating tumor cells (CTCs) after mesenchymal transition in the blood of patients. Liposomal Hsp70 provides a promising biomarker for viable tumor mass in different tumor entities and CTCs in the blood are presently evaluated as valuable tools for prediction of clinical responses and therapy resistance of cancer.

Prof. Multhoff’s research interests also include the application of novel in vivo imaging techniques such as intraoperative, fluorescence molecular tomography (FMT), multispectral optoacoustic tomography (MSOT) and PET/CT in small animals after CT-guided irradiation of tumors using the small animal radiation research platform SARRP (DFG INST411/37-1 FUGG) and the analysis of cellular, molecular biological and immunological mechanisms in tumor and normal cells including primary endothelial cells after exposure to radiation, as well as the development of innovative nanoparticle-based theranostica.

Awards

  • ISOTT Preis (International Society on Oxygen Transport to Tissue) (2018)
  • CESAR Preis (Central European Society for Anticancer Drug Research) (2015)
  • Paula und Richard von Hertwig Preis der Helmholtzgemeinschaft (1998)
  • ESHO-BSD Preis (European Society of Hyperthermic Oncology) (1996)
  • Young Investigator Award, VII International Congress on Hyperthermic Oncology (ICHO), (Society for Thermal Medicine) (1996)

Publications

 

1.      Müller-Eckhardt G, Meier-Ewert K, Schendel DJ, Reinecker FB, Multhoff G, Mueller-Eckhardt C: HLA and narcolepsy in a German population. Tissue Antigens 28: 163-169, 1986. (1.8)

2.      Issels RD, Meier T, Müller E, Multhoff G, Wilmanns W: Ifosfamide induced stress response in human lymphocytes. Molec Aspects Med 14: 281-286, 1993. (0.8)

3.      Meier T, Allenbacher A, Müller E, Multhoff G, Botzler C, Wiesnet M, Issels RD: Ifosfamide induced depletion of glutathione in human PBL and protection by mesna. Anti-Cancer Drugs 5: 403-409, 1994. (1.9)

4.      Alexandroff A, Jackson B, Multhoff G, Botzler C: NK cells, heat shock proteins, cell adhesion - structure and molecular mechanisms. Review based on 12th European Immunology Meeting. Russian Language. Immunologia 4: 70-72, 1996.

5.      Multhoff G, Meier T, Botzler C, Wiesnet M, Allenbacher A, Wilmanns W, Issels RD: Differential effects of ifosfamide upon the capacity of cytotoxic T lymphocytes and natural killer cells to lyse their target cells correlate with intracellular glutathione levels. Blood 85: 2124-2131, 1995. (10.1)

6.      Multhoff G, Botzler C, Wiesnet M, Müller E, Meier T, Wilmanns W, Issels RD: A stress-inducible 72 kDa heat shock protein is expressed on the cell surface of human tumor cells but not on normal cells. Int J Cancer 61: 272-279, 1995. (4.4)

7.      Multhoff G, Botzler C, Wiesnet M, Eissner G, Issels RD: CD3 negative large granular lymphocytes recognize a heat inducible immunogenic determinant associated with the 72 kD heat shock protein (HSP72) on human sarcoma cells. Blood 86: 1374-1382, 1995. (10.1)

8.      Eissner G, Kohlhuber F, Grell M, Ueffing M, Scheurich P, Hieke A, Multhoff G, Bornkamm GW, Holler E: Critical involvement of transmembrane TNF-alpha in endothelial programmed cell death mediated by ionizing radiation and bacterial endotoxin. Blood 86: 4184-4193, 1995. (10.1)

9.      Botzler C, Kolb H-J, Issels RD, Multhoff G: Noncytotoxic alkyl-lysophopholipid treatment increases sensitivity of leukemic K562 cells to lysis by NK cells. Int J Cancer 65: 633-638, 1996. (4.4)

10.   Multhoff G, Hightower L: Cell surface expression of heat shock proteins and the immune response. Review in: Cell Stress Chaperones 1(3): 167-176, 1996. (3.0)

11.   Multhoff G, Botzler C, Allenbacher A, Issels RD: Effects of ifosfamide on immunocompetent effector cells. Cancer Immunol Immunother 42(4): 251-254, 1996. (3.1)

12.   Botzler C, Issels R, Multhoff G: HSP72 cell surface expression on human lung carcinoma cells is associated with an increased sensitivity to lysis by adherent NK cells. Cancer Immunol Immunother 43: 226-230, 1996. (3.1)

13.   Botzler C, Kis K, Issels R, Multhoff G: A comparison of the effects of ifosfamide versus mafosfamide treatment on intracellular glutathione levels and immunological functions of immunocompetent lymphocyte subsets. Exp Hematol 25: 338-344, 1997. (4.0)

14.   Multhoff G: Heat shock protein 72, a hyperthermia-inducible immunogenic determinant on Ewing`s sarcoma and leukemic K562 cells. Int J Hyperthermia 13 (1): 39-48, 1997. (1.8)

15.   Lindner H, Holler E, Ertl B, Multhoff G, Schreglmann M, Klauke I, Schultz-Hector S, Eissner G: Peripheral blood mononuclear cells induce programmed cell death in human endothelial cells and may prevent repair - role of cytokines. Blood 89(6): 1931-1938, 1997. (10.1)

16.   Multhoff G, Botzler C, Jennen L, Schmidt J, Ellwart J, Issels R: Heat shock protein cell surface expression on colon carcinoma cells correlates with the sensitivity to lysis mediated by NK cells. J Immunol 158: 4341-4350, 1997. (7.0)

17.   Mariethoz E, Jacquier-Sarlin M, Multhoff G, Healy A, Tacchini-Cottier F, Polla B: Heat shock and proinflammatory stressors induce differential localization of heat shock proteins in human monocytes: relationship to regulation and function. Inflammation 21(6): 629-642, 1997. (1.4)

18.   Bergeron J, Craig E A, Horvich A L, Langer T, Multhoff G, Smith D F, Hightower L E: Meeting report: Molecular chaperones in Biology and Medicine. Cell Stress Chaperones 2 (4): 220-228, 1997. (3.0)

19.   Multhoff G, Botzler C, Issels R: The role of HSP in the stimulation of an immune response. Biol Chem 379: 295-300, 1998. (3.4)

20.   Botzler C, Li G, Issels R, Multhoff G: Definition of extracellular localized epitopes involved in an NK mediated immune response. Cell Stress Chaperones 3(1): 6-11, 1998. (3.0)

21.   Multhoff G, Botzler C: Heat shock proteins and the immune response. Annals of the New York Academy of Sciences 851: 86-94, 1998. (0.2)

22.   Eissner G, Multhoff G, Holler E: Influence of bacterial endotoxin on the allogenicity of human endothelial cells. Bone Marrow Transplantation 16: 1286-1288, 1998. (2.1)

23.   Botzler C, Schmidt J, Luz A, Jennen L, Issels R, Multhoff G: Differential Hsp70 plasma membrane expression on primary human tumors and metastases in mice with severe combined immunodeficiency. Int J Cancer 77: 942-948, 1998. (3.7)

24.   Multhoff G: Tumor-specific Hsp70 cell surface expression and the NK-mediated immune response. Cell Stress Chaperones 3 (1): 6-7, 1998. (3.0)

25.   Multhoff G, Falk M: Meeting report on the International Congress on Hyperthermia in clinical oncology, Venice 1998. Cell Stress Chaperones 4(1): 54-59, 1999. (3.0)

26.   Botzler C, Ellwart J, Günther W, Eissner G, Multhoff G: Synergistic effects of heat and ET-18OCH3 on membrane expression of Hsp70 and lysis of leukemic K562 cells. Exp Hematol 27: 470-478, 1999. (4.0)

27.   Multhoff G, Mizzen L, Winchester C, Milner, C, Wenk S, Eissner G, Kampinga H, Laumbacher, B, Johnson J: Hsp70 stimulates proliferation and cytolytic activity of NK cells. Exp Hematol 27: 1627-1636, 1999. (4.0)

28.   Lahm H, Allenbacher A, Hoeflich A, Fischer J R, Botzler C, Multhoff G, Wolf E, Sordat B: Differential growth factor responsiveness and receptor expression in primar and metastatic human colorectal carcinoma cells. Contr to Oncology 54: 317-323, 1999. (0.2)

29.   Multhoff G: Mobilisierung im Reagenzglas: Hitze-Schock-Proteine als Angriffspunkte für Natürliche Killerzellen. Review in: Blick in die Wissenschaft 12: 42-47, 1999. (0.2)

30.   Multhoff G, Pfister K, Botzler C, Jordan A, Scholz R, Schmetzer H, Burgstahler R, Hiddemann W: Adoptive transfer of human NK cells in mice with severe combined immunodeficiency inhibits tumor growth and metastatic dissemination. Int J Cancer 88: 791-797, 2000. (4.4)

31.   Hantschel M, Pfister K, Jordan A, Scholz R, Andreesen R, Schmitz G, Schmetzer H, Hiddemann W, Multhoff G: Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients. Cell Stress Chaperones 5(5): 438-442, 2000. (3.0)

32.   Hempel JM, Naumann A, Botzler C, Multhoff G, Schorn K: Nachweis einer humoralen Immunreaktivität gegen Innenohrproteine bei Patienten mit einer sensorineuralen Schwerhörigkeit. Laryngo-Rhino-Otologie 80, 237-244, 2000. (0.2)

33.   Multhoff G, Pfister K, Gehrmann M, Hantschel M, Gross C, Hafner M, Hiddemann W: A 14-mer Hsp70 peptide stimulates natural killer (NK) cell activity. Cell Stress Chaperones 6(4): 337-344, 2001. (3.0)

34.   Pfeiffer A, Böttcher A, Orso E, Kapinsky K, Nagy P, Bodnar A, Spreitzer I, Liebisch G, Drobnik W, Gempel K, Horn M, Holmer S, Hartung T, Multhoff G, Schütz G, Schindler HJ , Ulmer A, Heine H, Stelter F, Schütt C, Rothe G, Szöllösi J, Damjanovich S, and Schmitz G: Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts. Eur J Immunol 31: 3153-3164, 2001. (4.5)

35.   Gehrmann M, Hantschel M, Pfister K, Gastpar R, Andreesen R, Schmetzer H, Haferlach T, Schnittger S, Schoch C, Kolb HJ, Hiddemann W, Multhoff G: Membrane expression of Hsp70 in hematological malignancies. European J Cancer 37 Suppl 3 2001. (3.7)

36.   Hantschel M, Moser C, Schmidbauer C, Jauch KW, Multhoff G: Cancer and chaperone – Hsp70 membrane expression as a target recognition structure for a cellular immunotherapy. J Cancer Res Clin Oncol Suppl p135, 2002. (1.0)

37.   Pfister K, Hager, Jauch KW, Multhoff G: Hsp70 Expression auf dem Kolorektalem Karzinom. Proktoonkologe 2002. (0.2)

38.   Eissner G, Multhoff G, Gerbitz A, Kirchner S, Bauer S, Haffner S, Sondermann D, Andreesen R, Holler E: Fludarabine induces apoptosis, activation and allogenicity in human endothelial cells, protective effect of defibrotide. Blood 100: 334-340, 2002. (10.1)

39.   Gehrmann M, Pfister K, Hutzler P, Gastpar R, Margulis B, Multhoff G: Effects of antineoplastic agents on cytoplasmic and membrane-bound Hsp70 levels. Biol Chem 383: 1715-1725, 2002. (3.4)

40.   Multhoff G: Activation of NK cells by Hsp70 protein. Review in: Int J Hyperthermia 18: 576-585, 2002. (1.8)

41.   Pfister K, Dietl B, Fürst A, Multhoff G, Jauch KW: Die Bedeutung der Bluttransfuion in der kolorektalen Tumorchirurgie. Significance of blood transfusion in colorectal cancer. Viszeral Chirurgie 37: 243-249, 2002. (0.2)

42.   Moser C, Schmidbauer C, Pfister K, Gürtler U, Gross C, Gehrmann M, Thonigs G, Pfister K, Multhoff G: Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by Hsp70-peptide-activated, CD94 positive natural killer cells. Cell Stress Chaperones 7 (4): 365-373, 2002. (3.0)

43.   Farkas B, Hantschel M, Becker B, Scherer K, Landthaler M, Pfister K, Gehrmann M, Mackensen A, Multhoff G: In melanoma metastases Hsp70 membrane expression is associated with a negative Mel-5 phenotype. Melanoma Res 13: 147-152, 2003. (1.4)

44.   Gross C, Hansch D, Gastpar R, Multhoff G: Interaction of Hsp70 peptide with NK cells involves the NK receptor CD94. Biol Chem 384: 267-279, 2003. (3.4)

45.   Gehrmann M, Schmetzer H, Eissner G, Haferlach T, Hiddemann W, Multhoff G: Membrane-bound Hsp70 in acute myeloid leukemia: a tumor-specific recognition structure for the cytolytic activity of autologous NK cells. Haematologica 88: 473-475, 2003. (3.5)

46.   Becker B, Multhoff G, Farkas B, P-J. Wild, Landthaler M, Stolz W, Vogt T: Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases. Exp Dermatol 13: 27-32, 2004. (2.0)

47.   Kleinjung T, Arndt O, Feldmann HJ, Bockmühl U, Gehrmann M, Zilch T, Pfister K, Schönberger J, Marienhagen J, Eilles C, Rossbacher L, Multhoff G. Heat shock protein 70 (Hsp70) membrane expression on head and neck cancer biopsy – a target for NK cells. Int J Rad Oncol Biol Phys 57 (3): 820-826, 2003. (4.2)

48.   Pfister K, Löwel I, Multhoff G, Fürst A, Hager T. Ist eine kolonpouchanale Rekonstruktion beim tief sitzenden Rektumkarzinom sinnvoll? Coloproctology 25: 3-9, 2003. (0.2)

49.   Gross C, Schmidt-Wolf IK, Nagaraj S, Ellwart J, Kunz-Schughart L, Multhoff G: Hsp70-reactivity is associated with increased cell surface density of CD94 and CD56. Cell Stress Chaperones 8(4): 348-360, 2003. (3.0)

50.   Gross C, Koelch W, Arispe N, DeMaio A, Multhoff G: Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B. J Biol Chem 17: 41173-41181, 2003. (7.7)

51.   Gastpar R, Gross C, Rossbacher L, Ellwart J, Riegger J, Multhoff G: Soluble Hsp70-peptide induces both, migration and cytolytic activity in CD3-CD94+CD56+ NK cells. J Immunol 172: 972-980, 2004. (7.0)

52.   Pfister K, Peleikis A, Fürst A, Multhoff G, Hager T. Adjuvant radiochemotherpay. Does it use after total mesorectal excision  improve the rates of local recurrence and/or the survival rates in patients with rectal carcinoma? Chirurgische Praxis 62(3): 373-382, 2004. (0.2)

53.   Gehrmann M, Brunner M, Pfister K, Reichle A, Kremmer E, Multhoff G: Differential up-regulation of cytosolic and membrane-bound heat shock protein 70 (Hsp70) in tumor cells by anti-inflammatory drugs. Clin Cancer Res 10: 3354-3364, 2004. (6.5)

54.   Krause S, Gastpar R, Andreesen R, Gross C, Ullrich H, Thonigs G, Pfister K, Multhoff G: Treatment of cancer patients with autologous ex vivo Hsp70-peptide activated NK cells: a clinical phase I trial. Clinical Cancer Res 10: 3699-3707, 2004. (6.5)

55.   Nylandsted J, Hansen MG, Danielewich A, Fehrenbach N, Hoyer-Hansen M, Lademann U, Multhoff G, Rohde M, Jäättelä M. Hsp70 promotes tumour cell survival by inhibiting lysosomal membrane permeabilization. J Exp Med 200(4): 425-435, 2004. (15.2)

56.   Gehrmann M, Marienhagen J, Eichholtz-Wirth H, Fritz E, Ellwart J, Jäättelä M, Zilch T, Multhoff G: Protection against gamma-irradiation-induced effects is associated with an increased heat shock protein 70 (Hsp70)/ Bag-4 membrane expression on carcinoma cells. Cell Death and Differentiation 12: 38-51, 2005. (7.0)

57.   Gehrmann M, Gross C, Dickinson A, Kolb HJ, Hiddemann W, Multhoff G: Hsp70 membrane expression, a leukaemia-specific marker in different haematological malignancies. Immunology 88: 505-509, 2004. (2.9)

58.   Lechin F, van der Dijs B, Lechin AE, Multhoff G, Pfister K, Hromadnikova I, Zlacka D. Natural killer cell activity and neuroimmunological treatment of cancer. Letter to the editor. Clinical Cancer Res 10: 8120-8121, 2004. (6.5)

59.   Bausero MA, Gastpar R, Ogawa K, Multhoff G, Asea A: Alternative mechanisms by which IFN-gamma enhances tumor recognition: active release of Hsp72. J Immunol 175: 2900-2912, 2005. (7.0)

60.   Gehrmann M, Schönberger J, Zilch T, Rossbacher L, Thonigs G, Eilles C, Multhoff G: Retinoid- and sodium-butyrate induced decrease in heat shock protein 70 membrane-positive tumor cells is associated with reduced sensitivity to NK cell lysis, growth delay, and altered growth morphology. Cell Stress Chaperones 10(2): 136-146, 2005. (3.0)

61.   Hightower LE: Introducing Professor Gabriele Multhoff, European Regional Editor. Cell Stress Chaperones 10(1): 2-3, 2005. (3.0)

62.   Gastpar R, Gehrmann M, Bausero M, Asea A, Gross C, Schroeder J, Multhoff G: Hsp70 surface-positive tumor-exosomes stimulate migratory and cytolytic activity of NK cells. Cancer Res 65(12): 5238-5247, 2005. (8.6)

63.   Radons J, Gross C, Multhoff G: Nucleofection of non-B cells with mini-Epstein Barr virus DNA. J Immunol Methods 303: 135.141, 2005. (3.0)

64.   Radons J, Multhoff G: Review Immunostimulatory functions of membrane-bound and exported Hsp70. Exercise Immunol Rev 11: 17-33, 2005. (4.6)

65.   Stangl S, Wortmann A, Gürtler U, Multhoff G: Control of metastasized pancreatic carcinomas in SCID/beige mice with human TKD-activated NK cells. J Immunol 176 (10): 6270-6276, 2006 (7.0)

66.   Nguyen TT, Gehrmann M, Zlacka D, Sosna A, Vavarincova P, Multhoff G, Hromadnikova I. Hsp70 membrane expression on fibroblast-like synovial cells derived from synovial tissue of patients with rheumatoid and juvenile arthritis. Scand J Rheumatol 35 (6): 447-453, 2006. (2.0) 

67.   Schmitt E, Gehrmann M, Brunet M, Multhoff G, Garrido C: Intracellular and extracellular functions of heat shock proteins: repercussion in cancer therapy. Review J Leukocyte Biol 81 (1): 15-27, 2007 (8.0)

68.   Radons J, Stangl S, Multhoff G: NK cell-based immunotherapies against solid tumors. Central European Journal of Medicine 1 (3): 179-204, 2006.

69.   Bogunia-Kubik K, Multhoff G: Investigating cellular stress responses – a multidisciplinary approach from basic science to therapeutics - Report on EuroSciCon (European Scientific Conferences) meeting. Cell Stress Chaperones 12 (2): 106-111, 2007.

70.   Multhoff G, DeMaio A: Stress down south: meeting report of the fifth International Workshop on the Molecular Biology of Stress Responses. Cell Stress Chaperones 11 (2): 108-115, 2006.

71.   Multhoff G: HSPs in immunity. Molecular Chaperones in Health and Disease In: Handbook of Experimental Pharmacology 172: 279-304, 2006.

72.   Gross C, Holler E, Stangl S, Dickinson A, Pockley G, Asea A, Mallappa N, Multhoff G: An Hsp70 peptide initiates NK killing of leukemic blasts after stem cell transplantation. Leukemia Res 32(4): 537-544, 2008.

73.   Steiner K, Graf M, Hecht K, Reif S, Rossbacher L, Pfister K, Kolb HJ, Schmetzer H, Multhoff G: High Hsp70 membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with worse prognosis. Leukemia 21: 93-101, 2007.

74.   Pfister K, Radons J, Busch R, Tidball J, Pfeifer M, Freitag L, Feldmann HJ, Milani V, Issels R, Multhoff G: Patient survival by Hsp70 membrane-phenotype: association with different routes of metastasis. Cancer 110(4): 926-935, 2007.

75.   Gehrmann M, Radons J, Molls M, Multhoff G: Review: The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells. Cell Stress Chaperones 13(1): 1-10, 2008.

76.   Sherman M, Multhoff G: Stress Responses in Biology and Medicine Ed Csermely P, Korcsmaros T, Sulyok K. Heat shock proteins in cancer. Ann N Y Acad Sci 1113: 192-201, 2007.

77.   Elsner L, Muppala V, Gehrmann M, Lozano J, Malzahn D, Bickeböller H, Brunner E, Zientkowska M, Hermann T, Walter L, Alves F, Multhoff G, Dressel R: The heat shock protein 70 (HSP70) promotes mouse NK cell activity against tumors which express inducible NKG2D ligands. J Immunol 179(8): 5523-5533, 2007.

78.   Vega V, Rodriguez-Silva M, Frey T, Gehrmann M, Diaz JC, Steinem C, Multhoff G, Aripse N, DeMaio A: Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. JI 180(6): 4299-4307, 2008.

79.   Stangl S, Gross C, Pockley AG, Asea A, Multhoff G: Influence of Hsp70 and HLA-E on the killing of leukemic blasts by cytokine/Hsp70 peptide activated human NK cells. Cell Stress Chaperones 13(2): 221-230, 2008.

80.   Kraetzel K, Stoelcker B, Eissner G, Multhoff G, Pfeifer M, Holler E, Schulz C: NKG2D-dependent effector function of bronchial epithelium-activated alloreactive T cells. Eur Resp Journal 32(3): 563-570, 2008.

81.   Gehrmann M, Liebisch G, Schmitz G, Anderson R, Steinem C, DeMaio A, Pockley AG, Multhoff G: Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3. Plos One 3(4):e1925, 2008.

82.   Multhoff G: Heat shock protein 70 (Hsp70): Membrane location, export and immunological relevance. Methods 43(3): 229-237, 2007.

83.   Horvath I, Multhoff G, Sonnleitner A, Vigh L: Membrane associated stress proteins: more than simply chaperones. Biochim & Biophys Acta (BBA) – Review. 1778 (7-8): 1653-1664, 2008.

84.   Pockley AG, Multhoff G: Cell stress proteins in extracellular fluids: friend or foe? Novartis Found Symp 291: 86-95, 2008.

85.   Multhoff G, Pockley G: Hsp70 export from tumor cells – a danger signal for the innate immune system. Medimond TSIS 2007.

86.   Schilling D, Gehrmann M, Steinem C, DeMaio A, Pockley AG, Abend M, Molls M, Multhoff G. Binding of Hsp70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells. FASEB 23(8): 2467-2477, 2009.

87.   Giraldo E, Martin-Cordero L, Garcia J J, Gerhmann M, Multhoff G, Ortega E. Exercise-induced extracellular 72 kDa heat shock protein (Hsp72) stimulates neutrophil phagocytic and fungicidal capacities via TLR-2. Eur J Appl Physiol 108(2): 217-225, 2009.

88.   Multhoff G. Hyperthermia classic Commentary: Activation of NK cells by Hsp70 Gabriele Multhoff, International Journal of Hyperthermia, 2002; 18: 576-585. Int. J Hyperthermia 25(3) 176-179, 2009.

89.   Multhoff G: Activation of natural killer cells by heat shock protein 70. 2002. Int J Hyperthermia 25(3): 169-175, 2009.

90.   Milani V, Stangl S, Issels R, Gehrmann M, Wagner B, Hube K, Mayr D, Hiddemann W, Molls M, Multhoff G. Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy--a case report. J. Transl. Med. 7: 50, 2009.

91.   Pockley A G, Calderwood S K, Multhoff G. The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions? Cell Stress Chaperones. 14(6): 545-553, 2009.

92.   Elsner L, Flugge P F, Lozano J, Muppala V, Eiz-Vesper B, Demiroglu S. Y, Malzahn D, Herrmann T, Brunner E, Bickeboller H., Multhoff G, Walter L, Dressel R. The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells. J. Cell Mol. Med. 14(4): 992-1002, 2010.

93.   Muthana M, Multhoff G, Pockley AG: Tumour infiltrating host cells and their significance for hyperthermia. Int J Hyperthermia. 26: 247-255, 2010.

94.   Chalmin F, Ladoire S, Mignot G, Vincent J, Bruchard M, Remy-Martin J P, Boireau W, Rouleau A, Simon B, Lanneau D, De T A, Multhoff G, Hamman A, Martin F, Chauffert B, Solary E, Zitvogel L, Garrido C, Ryffel B, Borg C, Apetoh L, Rebe C, Ghiringhelli F. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J. Clin. Invest 120(2): 457-471, 2010.

95.   Giraldo E, Multhoff G, Ortega E. Noradrenaline increases the expression and release of Hsp72 by human neutrophils. Brain Behav Immun 24(4): 672-677, 2010.

96.   Friedrich L, Stangl S, Hahne H, Kuster B, Kohler P, Multhoff G, Skerra A. Bacterial production and functional characterization of the Fab fragment of the murine IgG1/{lambda} monoclonal antibody cmHsp70.1, a reagent for tumour diagnostics. Protein Eng Des Sel 23(4): 161-168, 2010.

97.   Artman T, Schilling D, Gnann J, Molls M, Multhoff G,  Bayer C. Irradiation-induced regulation of plasminogen activator inhibitor type-1 and vascular endothelial growth factor in six human squamous cell carcinoma lines of the head and neck. Int J Radiat Oncol Biol Phys 76(2): 574-582, 2010.

98.   Stocki P, Morris N J, Preisinger C, Wang X N, Kolch W, Multhoff G, Dickinson A M. Identification of potential HLA class I and class II epitope precursors associated with heat shock protein 70 (HSPA). Cell Stress Chaperones 15(5): 729-741, 2010.

99.   Schulz U, Kreutz M, Multhoff G, Stoelcker B, Köhler M, Andreesen R, Holler E. Interleukin-10 promotes NK cell killing of autologous macrophages by stimulating expression of NKG2D ligands. Scand J Immunol 72(4): 319-331, 2010.

100.                  Gehrmann M, Schilling D, Molls M, Multhoff G. Radiation induced stress proteins. Int J Clin Pharmacol Ther 48(7): 492-493, 2010.

101.                  Multhoff G. Comment to: Humanization of a mouse monoclonal antibody directed against a cell surface-exposed epitope of membrane-associated heat shock protein 70 (Hsp70). Mol Biotechnol 46(2): 206-208, 2010.

102.                  Multhoff G, Gaipl U: Immunologische Aspekte bei der Krebsbehandlung und Behandlung benigner Erkrankungen nach Strahlenexposition. Strahlenschutzpraxis 4: 20-23, 2010.

103.                   Multhoff G, Gaipl U: Leitthema. Molekulare und immunologische Effekte der Hyperthermie auf Tumorprogression und Metastasierung. Der Onkologe 16: 1043-1051, 2010.

104.                  Riederer I, Sievert W, Eissner G, Multhoff G: Irradiation-induced differential expression of HLA-E affects lytic activity of NK cells. Plos One  5(12): e15339, 2010.

105.                  Donfack P, Multhoff G, Materny M: Label-free nondestructive discrimination of colon carcinoma sublines and biomolecular insights into their differential hsp70 expression: DNA/RNA nucleobase specific changes. Chembiochem 12(12): 1922-1936, 2011.

106.                   Giraldo E, Martin-Cordero L, Garcia JJ, Gehrmann M, Multhoff G, Ortega E. Erratum to: Exercise-induced extracellular 72 kDa heat shock protein (Hsp72) stimulates neutrophil phagocytic and fungicidal capacities via TLR-2. Eur J Appl Physiol, 111(11): 2883, 2011.

107.                  Multhoff G, Hightower LE: Distinguishing integral and receptor-bound heat shock protein 70 (Hsp70) on the cell surface by Hsp70 specific antibodies. Cell Stress Chaperones 16(3): 251-255, 2011.

108.                  Stangl S, Gehrmann M, Riegger J, Kuhs K, Riederer I, Sievert W, Hube K, Mocikat R, Dressel R, Kremmer E, Pockley AG, Friedrich L, Vigh L, Skerra A, Multhoff G: Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody. PNAS 108(2): 733-738, 2011.

109.                  Stangl S, Gehrmann M, Dressel R, Alves F, Dullin C, Themelis G, Ntziachristos V,      Staeblein E, Walch A, Winkelmann I, Multhoff G. In vivo imaging of CT26 mouse tumors by using cmHsp70.1 monoclonal antibody. J Cell Mol Med 15(4): 874-887, 2011.

110.                  Chaachouay H, Ohneseit P, Toulany M, Kehlbach R, Multhoff G, Rodemann HP: Autophagy contributes to resistance profile of tumor cells to ionising radiation. Radiother Oncol 99(3): 287-292, 2011.

 

111.                  Gehrmann M, Doss BT, Wagner M, Zettlitz KA, Kontermann RE, Foulds G, Pockley AG, Multhoff G. A novel expression and purification system for the production of enzymatic and biologically active human granzyme B. J Immunol Methods 371: 8-17, 2011.

112.                  Schildkopf P, Frey B, Ott OJ, Rubner Y, Multhoff G, Sauer R, Fietkau R, Gaipl US. Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages. Radiother Oncol 101(1): 109-115; 2011.

113.                  Stangl S, Themelis G, Friedrich L, Ntziachristos V, Sarantopoulos A, Molls M, Skerra A, Multhoff G. Detection of irradiation-induced, membrane heat shock protein 70 (Hsp70) in mouse tumors using Hsp70 Fab fragment. Radiother Oncol 99: 313-316, 2011.

114.                  Hoffmann J, Junker H, Schmieder A, Venz S, Brandt R, Multhoff G, Falk W, Radons J. EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells. Biochem Pharmacol 82(9): 1153-62, 2011.

115.                  Nagaraja GM, Kaur P, Neumann W, Asea EE, Bausero MA, Multhoff G, Asea A. Silencing hsp25/hsp27 Gene Expression Augments Proteasome Activity and Increases CD8+ T-Cell-Mediated Tumor Killing and Memory Responses. Cancer Prev Res (Phila) 5: 122-137, 2012.

116.                  Zlobinskaya O, Dollinger G, Michalski D, Hable V, Greubel C, Du G, Multhoff G, Roper B, Molls M, Schmid TE. Induction and repair of DNA double-strand breaks assessed by gamma-H2AX foci after irradiation with pulsed or continuous proton beams. Radiat Environ Biophys  1: 23-32, 2012.

 

117.                  Schilling D, Bayer C, Emmerich K, Molls M, Vaupel P, Huber RM, Multhoff G. Basal HIF-1α expression levels are not predictive for radiosensitivity of human cancer cell lines. Strahlenther Onkol 188(4): 353-358, 2012.

118.                  Multhoff G, Molls M, Radons J. Chronic inflammation in cancer development. Front Immunol 2: 98, 2012.

119.                  Schmid TE, Multhoff G. Radiation-Induced Stress Proteins – the Role of Heat Shock Proteins (HSP) in Anti-Tumor Responses. Curr Med Chem 19(12): 1765-1770, 2012.

120.                  Schilling D, Bayer C, Li W, Molls M, Vaupel P, Multhoff G. Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1α. PlosOne 7(2): e31110, 2012.

121.                  Böttger E, Multhoff G, Kun JFJ, Esen M. Plasmodium falciparum-infected erythrocytes induce Granzyme B by NKcells through expression of host-Hsp70. PlosOne                      7(3): e33774, 2012.

122.                  Härdtner C, Multhoff G, Falk W, Radons J. (-)-Epigallocatechin-3-gallate, a green tea-derived catechin, synergizes with celecoxib to inhibit IL-1-induced tumorigenic mediators by human pancreatic adenocarcinoma cells Colo357. Europ J of Pharmacol 684: 36-43, 2012.

123.                  Multhoff G, Radons J. Radiation, inflammation, and immune responses in cancer. Front Oncol 2: 58, 2012.

124.                  Bayer C, Kielow  A, Schilling  D, Maftei CA, Zips D, Yaromina  A, Baumann M, Molls M, Multhoff G. Monitoring PAI-1 and VEGF Levels in 6 Human Squamous Cell Carcinoma Xenografts During Fractionated Irradiation. Int J Radiat Oncol Biol Phys 84(3): e409-417, 2012.

125.                  Schmieder A, Multhoff G, Radons J. Interleukin-33 acts as a pro-inflammatory cytokine and modulates its receptor gene expression in highly metastatic human pancreatic carcinoma cells. Cytokine 60: 514-521, 2012.

126.                  Multhoff G, Pockley AG, Streffer C, Gaipl US. Dual Role of HeatShock Proteins (HSPs) in Anti-Tumor Immunity. Curr Mol Med 12: 1174-1182, 2012.

127.                  Schmid TE, Multhoff G. Non-targeted effects of photon and particle irradiation and the interaction with the immune system. Front Oncol 2:80, 2012.

128.                  Gehrmann M, Stangl S, Kirschner A, Foulds GA, Sievert W, Doß BT, Walch A, Pockley AG, Multhoff G. Immunotherapeutic Targeting of Membrane Hsp70-Expressing Tumors Using Recombinant Human Granzyme B. PlosOne 7(7): e41341, 2012.

129.                  Multhoff G, Gaipl US, Niedermann G. The role of radiotherapy in the induction of antitumor immune responses. Strahlenther Onkol 188(3): 312-315, 2012.

130.                  Schmid TE, Greubel C, Hable V, Zlobinskaya O, Michalski D, Girst S, Siebenwirth C, Schmid E, Molls M, Multhoff G, Dollinger G. Low LET protons focused to submicrometer shows enhanced radiobiological effectiveness. Phys Med Biol 57(19): 5889-5907, 2012.

131.                  Multhoff G, Vaupel P. Radiation-induced changes in microcirculation and interstitial fluid pressure affecting the delivery of macromolecules and nanotherapeutics to tumors. Front Oncol 2: 165, 2012.

132.                  Zlobinskaya O, Girst S, Greubel C, Hable V, Siebenwirth C, Walsh DWM, Multhoff G, Wilkens JJ, Schmid TE, Dollinger G. Reduced side effects by proton microchannel radiotherapy – study in a human skin model. Radiat Environ Biophys 52(1): 123-133, 2013.

133.                  Multhoff G, Trott KR. Screening von Genpolymorphismen verbessert die Vorhersage der Strahlentoxizität nicht. Strahlenther Onkol 189: 91-92, 2013.

134.                  Foulds GA, Radons J, Kreuzer M, Multhoff G, Pockley AG. Influence of tumors on protective anti-tumor immunity and the effects of irradiation. Front Oncol 14(3): 1-14, 2013.

135.                  Li W, Tsen F, Sahu D, Bhatia A, Chen M, Multhoff G, Woodley DT. Extracellular Hsp90 (eHsp90) as the Actual Target in Clinical Trials: Intentionally or Unintentionally. Int Rev Cell Mol Biol 303: 203-235, 2013.

136.                  Azimzadeh O, Sievert W, Sarioglu H, Yentrapalli R, Barjaktarovic Z, Sriharshan A, Ueffing M, Janik D, Aichler M, Atkinson M, Multhoff G, Tapio S. PPAR Alpha: A Novel Radiation Target in Locally Exposed Mus musculus Heart Revealed by Quantitative Proteomics. J Proteome Res 12(6): 2700-2714, 2013.

137.                  Multhoff G, Rödel F, Pockley AG, Gaipl US. Frontiers Research topic: radiation-induced effects and the immune system. Front Oncol 3: 55, 2013.

138.                  Schmid TE, Zlobinskaya O, Multhoff G. Differences in Phosphorylated Histone H2AX Foci Formation and Removal of Cells Exposed to Low and High Linear Energy Transfer Radiation. Curr Genomics 13(6): 418-425, 2013.

139.                  Schilling D, Düwel M, Molls M, Multhoff G. Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels. Cell Stress Chaperones 18(2): 183-191, 2013.

140.                  Gaca S, Reichert S, Multhoff G, Wacker M, Hehlgans S, Botzler C, Gehrmann M, Rödel C, Kreuter J, Rödel F. Targeting by cmHsp70.1-antibody coated and survivin miRNA plasmid loaded nanoparticles to radiosensitize glioblastoma cells. J Control Release 172(1): 201-206, 2013.

141.                  Tapfer A, Bech M, Zanette I, Symvoulidis P, Stangl S, Multhoff G, Molls M, Ntziachristos V, Pfeiffer F. Three-dimensional imaging of whole mouse models: comparing nondestructive X-ray phase contrast micro-CT with cryotome-based planar epi-illumination imaging. J Microsc 253(1): 24-30, 2014.

142.                  Bayer C, Liebhardt ME, Schmid TE, Trajkovic-Arsic M, Hube K, Specht HM, Schilling D, Gehrmann M, Stangl S, Siveke JT, Wilkens JJ, Multhoff G. Validation of Heat Shock Protein 70 as a Tumor-Specific Biomarker for Monitoring the Outcome of Radiation Therapy in Tumor Mouse Models. Int J of Rad Oncol 88(3): 694-700, 2014.

143.                  Sievert W, Tapio S, Breuninger S, Gaipl U, Andratschke N, Trott K-R, Multhoff G. Adhesion Molecule Expression and Function of Primary Endothelial Cells in Benign and Malignant Tissues Correlates with Proliferation. PlosOne 9(3): e91808, 2014.

144.                  Zlobinskaya O, Siebenwirth C, Greubel C, Hable V, Hertenberger R, Humble N, Reinhardt S, Michalski D, Röper B, Multhoff G, Dollinger G, Wilkens JJ, Schmid TE. The effects of ultra-high dose rate proton irradiation on growth delay in the treatment of human tumor xenografts in nude mice. Rad Res 181: 177-183, 2014.

145.                  Multhoff G, Radons J, Vaupel P. Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance. Cancers 6: 813-828, 2014.

146.                  Gaipl US, Multhoff G, Scheithauer H, Lauber K, Hehlgans S, Frey B, Rödel F. Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy. Immunoth 6(5): 597-610, 2014.

147.                  Gehrmann M, Specht HM, Bayer C, Brandstetter M, Chizzali B, Duma M, Breuninger S, Hube K, Lehnerer S, Van Phi V, Sage E, Schmid TE, Sedelmayr M, Schilling D, Sievert W, Stangl S, Multhoff G. Hsp70 – a biomarker for tumor detection and monitoring of outcome of radiation therapy in patients with squamous cell carcinoma of the head and neck. Rad Oncol 9: 131, 2014.

148.                  Gehrmann M, Cervello M, Montalto G, Cappello F, Gulino A, Knape C, Specht HM, Multhoff G. Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Front Immunol 5: 307, 2014.

149.                  Gehrmann M, Stangl S, Foulds GA, Oellinger R, Breuninger S, Rad R, Pockley AG, Multhoff G. Tumor Imaging and Targeting Potential of an Hsp70-Derived 14-Mer Peptide. PlosOne 9(8): e105344, 2014.

150.                  Stangl S, Varga J, Freysoldt B, Trajkovic-Arsic M, Siveke JT, Greten FR, Ntziachristos V, Multhoff G. Selective in vivo Imaging of syngeneic, spontaneous and xenograft tumors using a novel tumor cell-specific Hsp70 peptide-based probe. Cancer Res 74(23): 6903-6912, 2014.

151.                  Peter L, Mateus D, Chatelain P, Schworm N, Stangl S, Multhoff G, Navab N. Leveraging random forests for interactive exploration of large histological images. Med Image Comput Comput Assist Interv 17(Pt 1):1-8, 2014.

152.                  Pockley AG, Henderson B, Multhoff G. Extracellular cell stress proteins as biomarkers of human disease. Biochem Soc Trans 42(6): 1744-1751, 2014.

153.                  Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P et al. Concensus guidelines for the detection of immunogenic cell death. Oncoimmunology 3(9): e955691, 2014.

154.                  Seemann KM, Luysberg M, Révay Z, Kudejova P, Sagué BS, Cassinelli N, Loidl A, Ilicic K, Multhoff G, Schmid TE. Magnetic heating properties and neutron activation of tungsten-oxide coated biocompatible FePt core-shell nanoparticles. J Control Release 197: 131-137, 2015.

155.                  Breuninger S, Erl J, Knape C, Gunther S, Regel Y, Rödel F, Gaipl US, Thorsteinsdottir J, Giannitrapani L, Dickinson AM, Multhoff G. Quantitative analysis of liposomal Heat Shock Protein 70 (Hsp70) in the blood of tumor patients using a novel LipHsp70 ELISA. Clin Cellular Immunol 5: 5, 2015.

156.                  Azimzadeh O, Sievert W, Sarioglu H, Merl-Pham J, Yentrapalli R, Bakshi MV, Janik D, Ueffing M, Atkinson MJ, Multhoff G, Tapio S. Integrative Proteomics and Targeted Transcriptomics Analyses in Cardiac Endothelial Cells Unravel Mechanisms of Long-Term Radiation Induced Vascular Dysfunction. J Proteom Res 14: 1203-1219, 2015.

157.                  Rödel F, Frey B, Multhoff G, Gaipl U. Contribution of the immune system to bystander and non-targeted effects of ionizing radiation. Cancer Lett 356: 105-113, 2015.

158.                  Schilling D, Kühnel A, Konrad S, Tetzlaff F, Bayer C, Yaglom J, Multhoff G. Sensitizing tumor cells to radiation by targeting the heat shock response. Cancer Lett 360(2): 294-301, 2015.

159.                  Schilling D, Tetzlaff F, Konrad S, Li W, Multhoff G. A hypoxia-induced decrease of either MICA/B or Hsp70 on the membrane of tumor cells mediates immune escape from NK cells. Cell Stress Chaperones (1)20: 139-147, 2015.

160.                  Multhoff G, Pockley AG, Schmid TE, Schilling D. The role of heat shock protein 70 (Hsp70) in radiation-induced immunomodulation. Cancer Lett 368(2): 179-184, 2015.

161.                  Schilling D, Kühnel A, Tetzlaff F, Konrad S, Multhoff G. NZ28-induced inhibition of HSF1, SP1 und NF-kB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Cancer Immunol Immunother  64: 599-608, 2015.

162.                  Vicencio JM, Yellon DM, Sivaraman V, Das D, Boi-Doku C, Arjun S, Zheng Y, Riquelme JA, Kearney J, Sharma V, Multhoff G, Hall AR, Davidson SM. Plasma exosomes protect the myocardium from ischemia-reperfusion injury. JACC 65(15): 1525-1536, 2015.

163.                  Girst S, Marx C, Bräuer-Krisch E, Bravin A, Bartzsch S, Oelfke U, Greubel C, Reindl J, Siebenwirth C, Zlobinskaya O, Multhoff G, Dollinger G, Schmid TE, Wilkens JJ. Improved normal tissue protection by proton and X-ray microchannels compared to homogeneous field irradiation. Phys Med 31(6): 615-620, 2015.

164.                  Specht HM, Ahrens N, Blankenstein C, Duell T, Fietkau R, Gaipl US, Günther C, Gunther S, Habl G, Hautmann H, Hautmann M, Huber RM, Molls M, Offner R, Rödel C, Rödel F, Schütz M, Combs SE, Multhoff G. Heat shock protein 70 (Hsp70) peptide activated Natural Killer (NK) cells for the treatment of patients with non-small cell lung cancer (NSCLC) after radiochemotherapy (RCTx) – from preclinical studies to a clinical phase II trial. Front Immunol 6: 162, 2015.

165.                  Bergmann L, Brugger W, Herr W, Mackensen A, Multhoff G. Welche Chancen bietet die Immunonkologie für ein indikationsübergreifendes Langzeitüberleben? Oncol Res Treat 38(3): 6-11, 2015.

166.                  Summerer I, Unger K, Braselmann H, Schuettrumpf L, Maihoefer C, Baumeister P, Kirchner T, Niyazi M, Sage E, Specht HM, Multhoff G, Moertl S, Belka C, Zitzelsberger H. Circulating MicroRNAs as prognostic therapy biomarkers in head and neck cancer patients. Br J Cancer 113(1): 76-82, 2015.

167.                  Bergs WJ, Wacker MG, Hehlgans S, Piiper A, Multhoff G, Rödel C, Rödel F. The role of recent nanotechnology in enhancing the efficacy of radiation therapy. Biochim Biophys Acta 1856: 130-143, 2015.

168.                  Giannitrapani L, Multhoff G. The Role of HSP70 in the Diagnosis of HCC. Forum on Immunopathol Diseases Therapeutics 5(3-4): 137-143, 2014.

169.                  Murakami N, Kühnel A, Schmid TE, Ilicic K, Stangl S, Braun IS, Gehrmann M, Molls M, Itami J, Multhoff G. Role of membrane Hsp70 in radiation sensitivity of tumor cells. Radiat Oncol 10: 149, 2015.

170.                  Sievert W, Trott KR, Azimzadeh O, Tapio S, Zitzelsberger H, Multhoff G. Late proliferating and inflammatory effects on murine microvascular heart and lung endothelial cells after irradiation. Radiother Oncol 117(2): 376-381, 2015.

171.                  Schwarzer J, Multhoff G. Commentary to: ‘A comparison of two commercially available ELISA methods for the quantification of human plasma heat shock protein 70 during rest and exercise stress’ by Lee et al. 2015. Cell Stress Chaperones 20(6): 865-866, 2015.

172.                  Schmid TE, Friedland W, Greubel C, Girst S, Reindl J, Siebenwirth C, Ilicic K, Schmid E, Multhoff G, Schmitt, E, Kundrát, Dollinger G. Sub-micrometer 20 MeV protons or 45 MeV lithium spot irradiation enhances yields of dicentric chromosomes due to clustering of DNA double-strand breaks. Mutat Res Genet Toxicol Environ Mutagen 793: 30-40, 2015.

173.                  Gehrmann MK, Kimm MA, Stangl S, Schmid TE, Noël PB, Rummeny E, Multhoff G. Imaging of Hsp70-positive tumors with cmHsp70.1 antibody-conjuigated gold nanoparticles. Int J Nanomedicine 10: 5687-5700, 2015.

174.                  Chaachouay H, Fehrenbacher B, Toulany M, Schaller M, Multhoff G, Rodemann HP. AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro. Radiother Oncol 116(3): 409-416, 2015.

175.                  Pockley AG, Foulds GA, Oughton JA, Kerkvliet NI, Multhoff G. Immune cell phenotyping using flow cytometry. Curr Protoc Toxicol 66:18.8.1-18.8.34. doi: 10.1002/0471140856.tx1808s66, 2015.

176.                  Shevtsov MA, Nikolaev BP, Yakovleva LY, Parr MA, Marchenko YY, Eliseev I, Dobrodumov AV, Zlobina O, Zhakhov A, Ischenko AM, Pitkin E, Multhoff G. 70-kDa heat shock protein coated magnetic nanocarriers as a nanovaccine for induction of anti-tumor immune response in experimental glioma. J Control Release 220: 329-340, 2015.

177.                  Schmid TE, Friedland W, Greubel C, Girst S, Reindl J, Siebenwirth C, Ilicic K, Schmid E, Multhoff G, Schmitt E, Kundrát P, Dollinger G. Sub-micrometer 20MeV protons or 45MeV lithium spot irradiation enhances yields of dicentric chromosomes due to clustering of DNA double-strand breaks. Mutat Res Genet Toxicol Environ Mutagen 793: 30-40, 2015.

178.                  Gunther S, Ostheimer C, Stangl S, Specht HM, Mozes P, Jesinghaus M, Vordermark D, Combs SE, Peltz F, Jung MP, Multhoff G. Correlation of Hsp70 levels with gross tumor volume and composition of lymphocyte subpopulations in patients with squamous cell and adeno non-small cell lung cancer. Front Immunol 6: 556, 2015.

179.                  Shevtsov MA, Nikolaev BP, Ryzhov VA, Yakovleva LY, Marchenko YY, Parr MA, Rolich VI, Mikhrina AL, Dobrodumov AV, Pitkin E, Multhoff G. Ionizing radiation improves glioma-specific targeting of superparamagnetic iron oxide nanoparticles conjugated with cmHsp70.1 monoclonal antibodies (SPION-cmHsp70.1). Nanoscale 7: 20652-20664, 2015.

180.                  Garg AD, Galluzzi L, Apetoh L, et al. Molecular and translational classifications of DAMPs in immunogenic cell death. Front Immunol 6: 588, 2015.

181.                  Shevtsov MA, Nikolaev BP, Ryzhov VA, Yakovleva LY, Dobrodumov AV, Marchenko YY, Margulis BA, Pitkin E, Mikhrina AL, Guzhova IV, Multhoff G. Detection of experimental myocardium infarction in rats by MRI using heat shock protein 70 conjugated superparamagnetic iron oxide nanoparticle. Nanomedicine 12(3): 611-621, 2015.

182.                  Sage EK, Schmid TE, Sedelmayr M, Gehrmann M, Geinitz H, Duma MN, Combs SE, Multhoff G. Comparative analysis of the effects of radiotherapy versus radiotherapy after adjuvant chemotherapy on the composition of lymphocyte subpopulations in breast cancer patients. Radiother Oncol 118(1): 176-180, 2015.

183.                  Isernhagen A, Schilling D, Monecke S, Shah P, Elsner L, Walter L, Multhoff G, Dressel R. The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA. Immunogenetics 68(2): 109-123, 2016.

184.                  Girst SE, Greubel C, Reindl J, Siebenwirth C, Zlobinskaya O, Walsh DWM, Ilicic K, Aichler M, Walch A, Wilkens JJ, Multhoff G, Dollinger G, Schmid TE. Proton minibeam radiation therapy reduces side effects in an in vivo mouse ear model. Int J Radiat Oncol Biol Phys 95(1): 234-241, 2016.

185.                  Combs SE, Schmid TE, Vaupel P, Multhoff G. Stress Response Leading to Resistance in Glioblastoma-The Need for Innovative Radiotherapy (iRT) Concepts. Cancers 8(1): E15, 2016.

186.                  Balermpas P, Rödel F, Rödel C, Krause M, Linge A, Lohaus F, Baumann M, Tinhofer I, Budach V, Gkika E, Stuschke M, Avlar M, Grosu AL, Abdollahi A, Debus J, Bayer C, Stangl S, Belka C, Pigorsch S, Multhoff G, Combs SE, Mönnich D, Zips D, Fokas E. CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German cancer consortium radiation oncology group (DKTK-ROG). Int J Cancer 138(1): 171-181, 2016.

187.                  Vaupel P, Multhoff G. Adenosine can thwart antitumor responses elicited by radiotherapy. Strahlenther Onkol 192(5): 279-287, 2016.

188.                  Multhoff G, Habl G, Combs SE. Rationale of hyperthermia for radio(chemo)therapy and immune responses in patients with bladder cancer: Biological concepts, clinical data, interdisciplinary treatment decisions and biological tumour imaging. Int J Hyperthermia 32(4): 455-463, 2016.

189.                  Isernhagen A, Malzahn D, Monecke S, Schilling D, Shah P, Multhoff G, Wulf G, Kube, D, Bickeböller H, Dressel R. Functional consequences of genetic polymorphisms in the NKG2D receptor signaling pathway and putative gene interactions. RCI: e1269, 2016.

190.                  Shevtsov M, Multhoff G. Heat shock protein-peptide and HSP-based immunotherapies for the treatment of cancer. Front Immunol 7: 171, 2016.

191.                  Kinzel L, Ernst A, Orth M, Albrecht V, Hennel R, Brix N, Frey B, Gaipl US, Zuchtriegel G, Reichel CA, Blutke A, Schilling D, Multhoff G, Li M, Niyazi M, Friedl AA, Winssinger N, Belka C, Lauber K. A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptososis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer. Oncotarget 7(28): 43199-43219, 2016.

192.                  Shevtsov MA, Multhoff G. Recent developments of magnetic nanoparticles for theranostics of brain tumor. Curr Drug Metab 17(8): 737-744, 2016.

193.                  Tzoumas S, Nunes A, Olefir I, Stangl S, Symvoulidis P, Glasl S, Bayer C, Multhoff G, Ntziachristos V. Eigenspectra optoacustic tomography achieves quantitative blood oxygenation imaging deep in tissues. Nat Commun 7: 12121, 2016.

194.                  Shevtsov MA, Parr MA, Ryzhof VA, Zemtsova EG, Arbenin AY, Ponomareva AN, Smirnov VM, Multhoff G. Zero-valent Fe confined mesoporous silica nanocarriers (Fe(0)@ MCM-41)for targeting experimental orthotopic glioma in rats. Sci Rep 6: 29247, 2016.

195.                  Vaupel P, Multhoff G. Commentary: A Metabolic immune checkpoint: Adenosine in tumor microenvironment. Front Immunol 7: 332, 2016.

196.                  Schulz D, Wirth M, Piontek G, Buchberger AMS, Schlegel J, Reiter R, Multhoff G, Pickhard A. HNSCC cells reistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances. Am J Cancer Res 6(9): 1963-1975, 2016.

197.                  Shevtsov M, Multhoff G. Immunological and translational aspects of NK cell-based antitumor immunotherapies. Front Immunol 7: 492, 2016.

198.                  Juric MK, Shevtsov M, Mozes P, Ogonek J, Crossland RE, Dickinson AM, Greinix HT, Holler E, Weissinger EM, Multhoff G. B-cell-based and soluble biomarkers in body liquids for prediting acute/chronic Graft-versus-Host Disease after allogeneic hematopoietic stem cell transplantation. Front Immunol 7: 660, 2017.

199.                  Schilling D, Garrido C, Combs S, Multhoff G. The Hsp70 inhibiting peptide aptamer A17 potentiates radiosensitization of tumor cells by Hsp90 inhibition. Cancer Lett 390: 146-152, 2017.

200.                  Peter L, Mateus D, Chatelain P, Declara D, Schworm N, Stangl S, Multhoff G, Navab N. Assisting the examination of large histopathological slides with adaptive forests. Med Image Anal 35: 655-668, 2017.

201.                  Walsh DWM, Siebenwirth C, Greubel C, Ilicic K, Reindl J, Girst S, Muggiolu G, Simon M, Barberet P, Seznec H, Zischka H, Multhoff G, Schmid TE, Dollinger G. Live cell imaging of mitochondria following targeted irradiation in situ reveals rapid and highly localized loss of membrane potential. Sci Rep 7: 46684, doi: 10.1038/srep46684, 2017.

202.                  Combs S, Multhoff G, Hildebrandt M, Ahrens N. Nicht-kleinzelliges Lungenkarzinom Zielgerichtete adjuvante Immuntherapie mit Natürlichen Killer (NK) Zellen zur Behandlung von Patienten nach Radiochemotherapie. Forum: Sektion B, 2017.

203.                  Balermpas P, Rödel F, Krause M, Linge A, Lohaus F, Baumann M, Tinhofer I, Budach V, Sak A, Stuschke M, Gkika E, Grosu AL, Abdollahi A, Debus J, Stangl S, Ganswindt U, Belka C, Pigorsch S, Multhoff G, Combs SE, Welz S, Zips D, Lim SY, Rödel C, Fokas E; DKTK-ROG. The PD-1/PD-L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG). Int J Cancer 141(3): 594-603, doi: 10.1002/ijc.30770, 2017.

204.                  Zahnreich S, Brieger J, Multhoff G, Vaupel P, Schmidberger H, Mayer A. The tumor microenvironment induces EGFR downregulation in squamous cell carcinomas of the head and neck. Strahlenther Onkol 193 (P07-2): S1-S194, 2017.

205.                  Schmid TE, Greubel C, Ilicic K, Walsh DWM, Reindl J, Siebenwirth C, Sammer M, Wilkens JJ, Multhoff G, dollinger g, Schmid E, Combs SE. Submicrometer focusing of low LET protons – understanding the RBE of heavy ion irradiation. Strahlenther Onkol 193 (P10-7): S1-S194, 2017.

206.                  Schilling D, Combs SE, Multhoff G. Increased MICA serum levels do not affect the NKG2D expression of NK cells in lung cancer patients.  Strahlenther Onkol 193 (P10-12): S1-S194, 2017.

207.                  Sage EK, Schmid TE, Geinitz H, Gehrmann M, Sedelmayr M, Duma MN, Combs SE, Multhoff G. Effects of local radiotherapy on the composition of lymphocyte subpopulations in prostate and breast cancer patients. Strahlenther Onkol 193(8): 648-655, doi: 10.1007/s00066-017-1144-7, 2017.

208.                  Thorsteinsdottir J, Stangl S, Fu P, Guo K, Albrecht V, Eigenbrod S, Erl J, Gehrmann M, Tonn JC, Multhoff G, Schichor C. Overexpression of cytosolic, plasma membrane bound and extracellular heat shock protein 70 (Hsp70) in primary glioblastomas. J Neurooncol,  135(3): 443-452, doi: 10.1007/s11060-017-2600-z, 2017.

209.                  Combs SE, Kessel C, Wilkens JJ, Multhoff G, Schmid TE, Vaupel P, Trott KR, Berberat P, Atkinson MJ. Master of Science (MSc) Program in Radiation Biology: An Interdepartmental Course Bridging the Gap between Radiation-Related Preclinical and Clinical Disciplines to Prepare Next-Generation Medical Scientists. Front Oncol 22(7): 226,  doi: 10.3389/fonc.2017.00226, 2017.

210.                  Cossarizza A, Chang HD, Radbruch A et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur J Immunol 47(10): 1584-1797, doi: 10.1002/eji.201646632, 2017.

211.                  Ostheimer C, Gunther S, Bache M, Vordermark D, Multhoff G. Dynamics of heat shock protein 70 serum levels as a predictor of clinical response in non-small-cell lung cancer and correlation with the hypoxia-related marker osteopontin. Front Immunol 18(8): 1305, doi: 10.3389/fimmu.2017.01305, 2017.

212.                  Friedrich L, Kornberger P, Mendler CT, Multhoff G, Schwaiger M, Skerra A. Selection of an Anticalin® against the membrane form of Hsp70 via bacterial surface display and ist theranostic application in tumour models. Biol Chem 399(3): 235-252, doi: 10.1515/hsz-2017-0207, 2018.

213.                  Fang HY, Münch NS, Schottelius M, Ingermann J, Liu H, Schauer M, Stangl S, Multhoff G, Steiger K, Gerngroß C, Jesinghaus M, Weichert W, Kühl AA, Sepulveda AR, Wester HJ, Wang TC, Quante M. CXCR4 is a potential target for diagnostic PET/CT imaging in Barrett's dysplasia and esophageal adenocarcinoma. Clin Cancer Res 24(5): 1048-1061, doi: 10.1158/1078-0432.CCR-17-1756, 2018.

214.                  Stangl S, Tontcheva N, Sievert W, Shevtsov M, Niu M, Schmid TE, Pigorsch S, Combs SE, Haller B, Balermpas P, Rödel F, Rödel C, Fokas E, Krause M, Linge A, Lohhaus F, Baumann M, Tinhofer I, Budach V, Stuschke M, Grosu AL, Abdollahi A, Debus J, Belka C, Maihöfer C, Mönnich D, Zips D, Multhoff G. Heat shock protein 70 and tumor-infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG). Int J Cancer 142(9): 1911-1925, doi: 10.1002/ijc.31213, 2018.

215.                  Vaupel P, Multhoff G. Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor Immunity: Adenosine, Lactate, Acidosis, Vascular Endothelial Growth Factor, Potassium Ions, and Phosphatidylserine. Front Immunol 8: 1887, doi: 10.3389/fimmu.2017.01887, 2017.

216.                  Shevtsov M, Huile G, Multhoff G. Membrane heat shock protein 70: a theranostic target for cancer therapy. Philos Trans R Soc Lond B Biol Sci 373(1738), http://dx.doi.org/10.1098/rstb.2016.0526, 2018.

217.                  Stangl S, Foulds GA, Fellinger H, Pilkington GJ, Pockley AG, Multhoff G. (2018) Immunohistochemical and Flow Cytometric Analysis of Intracellular and Membrane-Bound Hsp70, as a Putative Biomarker of Glioblastoma Multiforme, Using the cmHsp70.1 Monoclonal Antibody. Methods Mol Biol 1709: 307-320, doi: 10.1007/978-1-4939-7477-1_22, 2018.

218.                  Lamprecht C, Gehrmann M, Madl J, Römer W, Multhoff G, Ebner A. Molecular AFM imaging of Hsp70-1A association with depalmitoyl phosphatidylserine reveals membrane blebbing in the presence of cholesterol. Cell Stress Chaperones 23(4): 673-683, https://doi.org/10.1007/s12192-018-0879-0, 2018.

219.                  Shevtsov M, Nikolaev B, Marchenko Y, Yakovleva L, Skvortsov N, Mazur A, Tolstoy P, Ryzhov V, Multhoff G. Targeting experimental orthotopic glioblastoma with chitosan-based superparamagnetic iron oxide nanoparticles (CS-DX-SPIONs). Int J Nanomedicine 13: 1471-1482. doi: 10.2147/IJN.S152461, 2018.

220.                  Subramanian V, Borchard S, Azimzadeh O, Sievert W, Merl-Pham J, Mancuso M, Pasquali E, Multhoff G, Popper B, Zischka H, Atkinson MJ, Tapio S. PPARα Is Necessary for Radiation-Induced Activation of Noncanonical TGFβ Signaling in the Heart. J Proteome Res  17(4): 1677-1689, doi: 10.1021/acs.jproteome.8b00001, 2018.

221.                  Sievert W, Stangl S, Steiger K, Multhoff G. Improved overall survival of mice by reducing lung side effects high-precision heart irradiation using a small animal radiation research platform. Int J Radiat Oncol Biol Phys 101(3): 671-679, doi: 10.1016/j.ijrobp.2018.02.017, 2018.

222.                  Schug C, Sievert W, Urnauer S, Müller AM, Schmohl KA, Wechselberger A, Schwenk N, Lauber K, Schwaiger M, Multhoff G, Wagner E, Nelson PJ, Spitzweg C. External beam radiation therapy enhances mesenchymal stem cell-mediated sodium iodide symporter gene delivery. Hum Gene Ther 29(11): 1287-1300, doi: 10.1089/hum.2018.025, 2018.

223.                  Lechner P, Buck D, Sick L, Hemmer B, Multhoff G. Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis. Mult Scler J Exp Transl Clin 4(2): 2055217318767192. doi: 10.1177/2055217318767192, 2018.

224.                  Shevtsov M, Zhou Y, Khachatryan W, Multhoff G, Gao H. Recent advances in gold nanoformulations for cancer therapy. Curr Drug Metab 19(9):768-780, doi: 10.2174/1389200219666180611080736, 2018.

225.                  Vaupel P, Multhoff G. Hypoxia-/HIF-1α-Driven Factors of the Tumor Microenvironment Impeding Antitumor Immune Responses and Promoting Malignant Progression. Adv Exp Med Biol 1072: 171-175, doi 10.1007/978-3-319-91287-5_27, 2018.

226.                  Stangl S, Tei L, De Rose F, Reder S, Martinelli J, Sievert W, Shevtsov M, Öllinger R, Rad R, Schwaiger M, D`Alessandria C, Multhoff G. Preclinical evaluation of the Hsp70 peptide tracer TPP-PEG24-DFO[89Zr] for tumor-specific PET/CT imaging. Cancer Res 78(21): 6268-628, doi: 10.1158/0008-5472.CAN-18-0707, 2018.

227.                  Breuninger S, Stangl S, Werner C, Sievert W, Lobinger D, Foulds GA, Wagner S, Pickhard A, Piontek G, Kokowski K, Pockley AG, Multhoff G. Membrane Hsp70 – A novel target for the isolation of circulating tumor cells after epithelial-to-mesenchymal transition. Front Oncol 8: 497, doi: https://doi.org/10.3389/fonc.2018.00497, 2018.

228.                  Reindl J, Shevtsov M, Dollinger G, Stangl S, Multhoff G. Membrane Hsp70-supported cell-to-cell connections via tunneling nanotubes revealed by live-cell STED nanoscopy. Cell Stress Chaperones 24(1): 213-221, doi: 10.1007/s12192-018-00958-w, 2019.

229.                  Balogi Z, Multhoff G, Jensen TK, Lloyd-Evans E, Yamashima T, Jäättelä M, Harwood JL, Vígh L. Hsp70 interactions with membrane lipids regulate cellular functions in health and disease. Prog Lipid Res 74:18-30, doi: 10.1016/j.plipres.2019.01.004, 2019.

230.                  Kokowski K, Stangl S, Seier S, Hildebrandt M, Vaupel P, Multhoff G. Radiochemotherapy combined with NK cell transfer followed by second-line PD-1 inhibition in a patient with NSCLC stage IIIb inducing long-term tumor control: a case study. Strahlenther Onkol 195(4): 352-361, https://doi.org/10.1007/s00066-019-01434-9, 2019.

231.                  Shevtsov M, Stangl S, Nikolaev B, Yakovleva L, Marchenko Y, Tagaeva R, Sievert W, Pitkin E, Mazur A, Tolstoy P, Galibin O, Ryzhov V, Steiger K, Smirnov O, Khachatryan W, Chester K, Multhoff G. Granzyme B functionalized nanoparticles targeting membrane Hsp70-positive tumors for multimodal cancer theranostics. Small 15(13): e1900205, doi: 10.1002/smll.201900205, 2019.

232.                  Shevtsov M, Sato H, Multhoff G, Shibata A. Novel approaches to improve the efficaciy of immune-radiotherapy. Front Oncol 19(9): 156, doi: 10.3389/fonc.2019.00156, 2019.

233.                  Shevtsov M, Pitkin E, Ischenko A, Stangl S, Khachatryan W, Galibin O, Edmond S, Lobinger D, Multhoff G. Ex vivo Hsp70-Activated NK cells in combination with PD-1 inhibition significantly increase overall survival in preclinical models of glioblastoma and lung cancer. Front Immunol 10: 454, doi: 10.3389/fimmu.2019.00454, 2019.

234.                  Rothammer A, Sage EK, Werner C, Combs SE, Multhoff G. Increased heat shock protein 70 (Hsp70) serum levels and low NK cell counts after radiotherapy – after potential markers for predicting breast cancer recurrence? Radiat Oncol 14(1): 78, doi: 10.1186/s13014-019-1286-0, 2019.

235.                  Schug C, Kitzberger C, Sievert W, Spellerberg R, Tutter M, Schmohl KA, Eberlein B, Biedermann T, Steiger K, Zach C, Schwaiger M, Multhoff G, Nelson PJ, Spitzweg C. Radiation-induced Amplification of TGFB1-induced Mesenchymal Stem Cell-mediated Sodium lodide Symporter (NIS) Gene 131 I Therapy. Clin Cancer Res: 25(19): 5997-6008, doi: 10.1158/1078-0432.CCR-18-4092, 2019.

236.                  Salvermoser L, Dressel S, Schleißheimer S, Stangl S, Diederichs C, Wergin M, Bley CR, Haller B, Multhoff G. Hsp70 serum levels in pet dogs-a potential diagnostic biomarker for spontaneous round cell tumors. Cell Stress Chaperones: 24(5): 969-978, doi: 10.1007/s12192-019-01024-9, 2019.

237.                  Kühnel A, Schilling D, Combs SE, Haller B, Schwab M, Multhoff G. Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922. Cells 8(10): 166. doi: 10.3390/cells8101166, 2019.

238.                  Cossarizza A, Chang HD, Radbruch A, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol 49(10): 1457-1973. doi: 10.1002/eji.201970107, 2019.

239.                  Shevtsov M, Multhoff G, Mikhaylova E, Shibata A, Guzhova I, Margulis B. Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors. Int J Mol Sci 20(21): E5284. doi: 10.3390/ijms20215284, 2019.

240.  Pockley AG, Vaupel P, Multhoff G. NK cell-based therapeutics for lung cancer. Expert Opin Biol Ther 20(1):23-33, doi: 10.1080/14712598.2020.1688298, 2020.

241.       Multhoff G, Vaupel P. Hypoxia Compromises Anti-Cancer Immune Responses. Adv Exp Med Biol. 1232: 131-143, doi: 10.1007/978-3-030-34461-0_18, 2020.

242.       Jos P, Sievert W, Azimzadeh O, Toerne C, Metzger F, Posch A, Hladik D, Subedi P, Multhoff G, Atkinson MJ, Tapio S. Data independent acquisition mass spectrometry of irradiated mouse lung endothelial cells reveals a STAT-associated inflammatory response. Int J Radiat Biol, doi.org/10.1080/09553002.2020.1712492, 2020.

243.       Vaupel P, Multhoff G. Fatal Alliance of Hypoxia-/HIF-1α-Driven Microenvironmental Traits Promoting Cancer Progression. Adv Exp Med Biol 1232: 169-176, doi: 10.1007/978-3-030-34461-0_21, 2020.

244.       Li WB, Belchior A, Beuve M, Chen YZ, Di Maria S, Friedland W, Gervais B, Heide B, Hocine N, Ipatov A, Klapproth AP, Li CY, Li JL, Multhoff G, Poignant F, Qiu R, Rabus H, Rudek B, Schuemann J, Stangl S, Testa E, Villagrasa C, Xie WZ, Zhang YB. Intercomparison of dose enhancement ratio and secondary electron spectra for gold nanoparticles irradiated by X-rays calculated using multiple Monte Carlo simulation codes. Phys Med 69: 147-163, doi: 10.1016/j.ejmp.2019.12.011, 2020.

245.       Issels RD, Lindner LH, Bergwelt-Baildon M, Lang P, Rischpler C, Diem H, Mosetter B, Eckl J, Schendel DJ, Salat C, Stötzer O, Burdach S, Luettichau-Teichert I, Handgretinger R, Neumann J, Kirchner T, Steiger K, Boxberg M, Mansmann U, Multhoff G, Noessner E. Systemic antitumor effect by regional hyperthermia combined with low-dose chemotherapy and immunologic correlates in an adolescent patient with rhabdomyosarcoma – a case report. Int J Hyperther 37(1): 55-65, 2020.

246.       Estrada H, Rebling J, Sievert W, Hladik D, Hofmann U, Gottschalk S, Tapio S, Multhoff G, Razansky. Intravital optoacoustic and ultrasound bio-microscopy reveal radiationinhibited skull angiogenesis. Bone 133: 115251, 2020.

247.       Gaipl US, Multhoff G, Pockley AG, Rödel F. Editorial: Radioimmunotherapy – Translational Opportunities and Challenges. Front Oncol 10: 190, doi: 10.3389/fonc.2020.00190, 2020.