Immune Signals and Cancer

Jürgen Ruland

Prof. Ruland studied medicine in Giessen and Pittsburgh with a degree in pharmacology. After medical and research work at TUM, Freiburg University, the Ontario Cancer Institute and the AMGEN Research Institute at the University of Toronto, he became head of a junior research group of the German Cancer Aid at TUM in 2003. He completed his postdoctoral studies in medicine in 2005 and served as professor of molecular immunology at TUM from 2010 to 2012. In 2012, he was appointed professor of clinical chemistry at TUM. He is member of the National Academy of Sciences Leopoldina, the Bavarian Academy of Sciences and Humanities and the German Cancer Aid committee for promoting young medical professionals and scientists. He is the spokesperson for the SFB 1335 "Aberrant Immune Signals in Cancer" and successfully raised his second ERC Advanced Grant in 2019.

 

Research Focus

The research conducted in Jürgen Ruland’s laboratory concentrates on signaling processes in the immune system, both under normal conditions and when deregulated in disease, particularly in cancer. By characterizing genetic alterations found in human lymphomas, which are frequently immune cell malignancies, he identified the molecular mechanisms by which antigen receptors activate the transcription factor NF-ƘB. This work explained how deregulation of these processes drives oncogenic growth. Within these pathways, the group further discovered that the enzymatic activity of a protein called Malt1 is critical for lymphoma cell survival. This initiated the pharmaceutical development of Malt1 inhibitors for lymphoma treatment. In addition, Ruland’s laboratory contributed key findings to our understanding of the innate immune system. The group was able to isolate several molecular switches that integrate immune signals from pattern recognition receptors after microbial pathogen sensing.
These findings led to fundamental insights into mammalian defense and to the discovery of human immune defects that cause high susceptibility to infection. The group continues to investigate the pathophysiology of immune signaling pathways in host protection, inflammation and cancer by engineering and analyzing relevant disease models to further contribute to strategies for immune manipulation and the establishment of new biomarkers.

Personal Profile

Key Awards

  • ERC Advanced Grant (2013 & 2019)
  • Member of the Bavarian Academy of Sciences and Humanities (2016)
  • Member of the National Academy of Sciences Leopoldina (2015)
  • Advanced Investigator Award from the European Research Council (2013)
  • Paul Martini Prize from the Paul Martini Foundation (2010)
  • William Warner Award for Cancer Research from the William Warner Foundation (2010)
  • Science Award (Wissenschaftspreis) from the Arbeitsgemeinschaft für Internistische Onkologie (2007)
  • Artur-Pappenheim Award from the Deutsche Gesselschaft für Hämatologie und Onkologie (2006)

Selected Publications

  • Wartewig T, Kurgyis Z, Keppler S, Pechloff K, Hameister E, Ollinger R, Maresch R, Buch T, Steiger K, Winter C, Rad R, Ruland J: "PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis". Nature. 2017; 552: 121-125.
  • Roth S, Rottach A, Lotz-Havla AS, Laux V, Muschaweckh A, Gersting SW, Muntau AC, Hopfner KP, Jin L, Vanness K, Petrini JH, Drexler I, Leonhardt H, Ruland J: "Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1beta production". Nat Immunol. 2014; 15: 538-545.
  • Gross O, Poeck H, Bscheider M, Dostert C, Hannesschläger N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A, Tschopp J, Ruland J: „Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence”. Nature. 2009; 459: 433-6.
  • Gross O, Gewies A, Finger K, Schäfer M, Sparwasser T, Peschel C, Förster I, Ruland J: „Card9 controlls a non-TLR signalling pathway for innate anti-fungal immunity”. Nature. 2006; 442: 651-6.
  • Ruland J, Duncan GS, Elia A, del Barco Barrantes I, Nguyen L, Plyte S, Millar DG, Bouchard D, Wakeham A, Ohashi PS, Mak TW: „Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure”. Cell. 2001; 104: 33-42.
  • All publications (link: https://pubmed.ncbi.nlm.nih.gov/)