This content is only available in English
Excellent basic research combined with innovative technology
TranslaTUM aims to combine the discovery culture of biology with aim of application, typical for the engineering sciences to solve quantitative problems of health and develop cutting-edge methods for earlier diagnosis and efficient prevention and treatment. Groundbreaking basic and applied interdisciplinary research will promote technological ability, increase our knowledge of cancer cell biology, and develop new concepts on the path from traditional biological observations to solutions that foster precise, personalized medicine. TranslaTUM focuses on three research pillars:
- Research signal transduction and interaction between tumor cells and the immune system
- Identification of target structures and molecules for diagnosis and treatment, and the design of new treatment paradigms that address complex systems
- Innovation of novel sensing, imaging and analysis techniques that will lead to earlier diagnosis of cancer and promote precision medicine
Our Research Groups
Cell Biology of Cancer
Florian Bassermann
Research in our lab focuses on the molecular pathophysiology and evolution of malignant diseases, particularly hematological neoplasms, such as B-cell malignancies and acute leukemias, as well as selected solid entities including lung cancer.
Immune Cell Signaling in Chronic Lymphocytic Leukemia
Maike Buchner
The focus of my Max Eder research group is to understand how signaling perturbations in malignant and normal B cells affect their survival and/or malignant spread in order to find new treatments.
Control and Manipulation of Microscale Living Objects
Ghulam Destgeer
Our research is focused on a range of topics including developing “acousto-microfluidics” platforms for contactless manipulation of micro/nano particles, cells, droplets, and microorganisms and “lab on a chip” technologies for single cell and single molecule analyses using droplet microfluidics platform.
Clinical Microbiome
Romana Gerner
We aim to understand how commensal and pathogenic microbes shape mucosal immunity and their impact on the development and progression of inflammatory and malignant diseases.
Pediatric Oncology
Julia Hauer
Pediatric oncology program at TranslaTUM is composed of two pillars (1) prevention of childhood cancer focusing in acute leukemia and (2) translational cellular immunotherapy and oncolytic virotherapy against pediatric sarcoma.
Biomedical Electronics
Oliver Hayden
Integration, simplicity and actionability are key requirements for diagnostics in the clinical routine as well as for decentralized healthcare applications. Based on these principles the Chair is developing platform technologies including workflow solutions for in vitro and in vivo diagnostics.
Personalized Oncology
Lena Illert
The aim of our research is the identification, validation, and translational, clinical implementation of novel target structures and predictive biomarkers to further precise molecularly targeted and personalized therapy strategies.
Immune Signalling
Julia Jellusova
The overarching goal of our research is to elucidate how metabolism and signal transduction are integrated in B cells in the normal and diseased state. B cells play a crucial role in our immune responses to pathogens. Reduced B cell activity can thus result in increased sensitivity to infections.
Imaging and Biomarkers in Oncology
Susanne Kossatz
In the research group “Imaging and Biomarkers in Oncology”, we develop biomarker-targeted approaches for molecularly selective tumor detection and therapy. We are exploring this approach in a wide range of tumor types, which are displaying patterns of overexpressed biomarkers on tumor cells.
Experimental Radiation Oncology and Radiobiology
Gabriele Multhoff
One of the focus areas of Prof. Gabriele Multhoff’s research work is the development of innovative cell-, molecule- and antibody-based targeted immunotherapies based on heat shock proteins. The aim is to combine these new therapeutic approaches with conventional radiation therapy and chemotherapy as a theragnostic.
Mechanobiology
Janna Nawroth
Our research focuses on the development of organ-on-chip systems, i.e. human organotypic microtissues cultured in a mechanically active microenvironment that mimics physiological cues and forces, such as fluid shear stresses, confinements, and strain.
Biological Imaging
Vasilis Ntziachristos
The Chair Biological Imaging (CBI) at the Technical University of Munich (TUM) focuses on the development and propagation of in vivo imaging technology to read novel, previously invisible processes and disease biomarkers.
Translational Optoacoustic
Miguel Pleitez
The general goal of my team in Translational Optoacoustic is to advance biological and biomedical research by achieving non-destructive live-cell chemical microscopy with label-free biomolecular sensitivity using molecule-specific mid-infrared excitation and highly-sensitive optoacoustic and optothermal detection.
Experimental Cancer Genetics
Roland Rad
Genome sequencing has provided tremendous insights into the mutational landscapes in cancer, but has also revealed that we are far from understanding the complexity of the molecular processes. To address these challenges, the Rad group has developed transposon-based screening technologies in mice.
AI in Healthcare and Medicine
Daniel Rückert
The Lab for AI in Medicine at TU Munich develops artificial intelligence (AI) and machine learning (ML) techniques to improve medicine for patients and healthcare professionals. Our aim is to address some of the key challenges in healthcare and medicine using AI.
Immune Signals and Cancer
Jürgen Ruland
My lab has a long standing interest in the molecular pathogenesis of lymphomas. Based on the functional characterization of recurrent chromosomal translocation in human MALT lymphomas, we identified the long sought-after molecular link that antigen receptors on lymphocytes utilize to activate the transcription factor NF κB.
Translational Cancer Research and Experimental Cancer Therapy
Dieter Saur
We are studying fundamental biologically and clinically relevant aspects of cancer: how it develops, progresses, spreads to distant sites, and why it becomes resistant to anti-cancer therapies.
Immunopathology and Signal Transduction
Marc Schmidt-Supprian
Immunopathologies include exaggerated responses to harmless substances, misguided responses against our own body, which can lead to autoimmune diseases and the uncontrolled expansion of immune cells, which in turn can cause cancer. We investigate the molecular and cellular mechanisms underlying such disorders.
CAR-T Cell Therapies
Andrea Schmidts
The focus of my Emmy Noether group is to understand and combat cancer cell resistance to CAR-T cell therapy. We aim to improve this innovative therapeutic approach and extend it to a broader patient population in clinical practice.
AI for Image-Guided Diagnosis and Therapy
Benedikt Wiestler
While medical imaging generates a vast amount of information, only a fraction is currently used to inform clinical decisions. We aim to bridge this gap by developing advanced algorithms and strategies that make this wealth of data accessible and actionable for clinicians.